For more than 30 years, we have been working every day to advance scientific research on rare genetic diseases and we do so by supporting the best researchers in Italy, through a transparent method that rewards projects with the greatest impact on patients' lives. Since 1990, the Telethon Foundation has invested over 623 million euros in research, funded 2,804 projects, involved 1,676 researchers and studied more than 580 diseases. We have achieved unique results by creating Strimvelis and Libmeldy, therapies that treat children with ADA-SCID and metachromatic leukodystrophy. Another 4 therapies are now in advanced clinical trials. We have also contributed to a better quality of life for many patients and named very rare diseases.